R-(+)-ETOMOXIR

Description Application

Product Name: R-(+)-ETOMOXIR
CAS No.: 124083-20-1
Chemical Name: R-(+)-ETOMOXIR
Synonyms: B80754;CS-1432;B807-54;B 80754;B-80754;B 807-54;B-807-54;S-(+)-ETOMOXIR;R-(+)-ETOMOXIR;R(+)-Etomoxir free acid
CBNumber: CB2407236
Molecular Formula: C17H23ClO4
Formula Weight: 326.82
MOL File: 124083-20-1.mol

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R-(+)-ETOMOXIR Property

Melting point:: 32-34°C
Boiling point:: 405.0±25.0 °C(Predicted)
Density: 1.163
storage temp.: Inert atmosphere,2-8°C
solubility: ≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming
form: Powder
InChI: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
InChIKey: DZLOHEOHWICNIL-QGZVFWFLSA-N
SMILES: O1C[C@]1(CCCCCCOC1=CC=C(Cl)C=C1)C(OCC)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E933505
Product name: R-(+)-Etomoxir
Packaging: 50mg
Price: $1620
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 10182
Product name: S-(+)-Etomoxir
Packaging: 25mg
Price: $2000
Updated: 2021/12/16

ApexBio Technology

Product number: A3404
Product name: Etomoxir
Packaging: 10mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002658
Product name: Etomoxir
Purity: 95.00%
Packaging: 10MG
Price: $303.45
Updated: 2021/12/16

ApexBio Technology

Product number: A3404
Product name: Etomoxir
Packaging: 50mg
Price: $510
Updated: 2021/12/16

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R-(+)-ETOMOXIR Chemical Properties,Usage,Production

Description

Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα. An off-target effect has been demonstrated at high concentrations of etomoxir on Coenzyme-A (CoA) metabolism.

Application

Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

Chemical Properties

Colourless Oil

Uses

An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug

Definition

ChEBI: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester is an aromatic ether.

Biological Activity

etomoxir is a cell-permeable, irreversible, and stereospecific compound. etomoxir is shown to inhibit carnitine palmitoyltransferase (cpt)-1 and dgat activity in the mitochondria of rat heart h9c2 myoblastic cells at a concentration of 1-80 μm and 40 μm, respectively.

R-(+)-ETOMOXIR Preparation Products And Raw materials

Raw materials

Preparation Products

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R-(+)-ETOMOXIR Suppliers

Canada 1 China 74 Germany 1 India 1 United States 13 Global 90

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

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View Lastest Price from R-(+)-ETOMOXIR manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Etomoxir 124083-20-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Etomoxir 124083-20-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Etomoxir 124083-20-1
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

124083-20-1, R-(+)-ETOMOXIRRelated Search:

(R)-(+)-Etomoxir sodium salt R-(+)-ETOMOXIR Etomoxir

(R)-2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylic acid ethyl ester

2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-

(2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid ethyl ester

ethyl (2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate

(2R)-2-[6-(4-Chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester

2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-(R)-(+)-Etomoxir

S-(+)-ETOMOXIR

(S)-2-[6-(4-CHLOROPHENOXY)HEXYL]OXIRANECARBOXYLIC ACID, ETHYL ESTER

R-(+)-ETOMOXIR

(R)-2-[6-(4-CHLOROPHENOXY)HEXYL]OXIRANECARBOXYLIC ACID, ETHYL ESTER

R(+)-Etomoxir free acid

CS-1432

R-(+)-ETOMOXIR USP/EP/BP

(R)-Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate

B807-54

B 80754

B 807-54

B80754

B-80754

B-807-54

124083-20-1

Chiral Reagents

Inhibitors